Differential Endothelial Transcriptomics Identifies Semaphorin 3G as a Vascular Class 3 Semaphorin

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Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.

OBJECTIVE To characterize the role of a vascular-expressed class 3 semaphorin (semaphorin 3G [Sema3G]). METHODS AND RESULTS Semaphorins have been identified as axon guidance molecules. Yet, they have more recently also been characterized as attractive and repulsive regulators of angiogenesis. Through a transcriptomic screen, we identified Sema3G as a molecule of angiogenic endothelial cells. ...

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Vascular endothelial-derived semaphorin 3 inhibits sympathetic axon growth.

Vascular sympathetic innervation is an important determinant of blood pressure and blood flow. The mechanisms that determine vascular sympathetic innervation are not well understood. Recent studies indicate that vascular endothelial cells (EC) express semaphorin 3A, a repulsive axon guidance cue. This suggests that EC would inhibit the growth of axons to blood vessels. The present study tests t...

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Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.

The axon guidance cues semaphorins (Semas) and their receptors plexins have been shown to regulate both physiological and pathological angiogenesis. Sema4A plays an important role in the immune system by inducing T cell activation, but to date, the role of Sema4A in regulating the function of macrophages during the angiogenic and inflammatory processes remains unclear. In this study, we show th...

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Growth Factor-A Expression in Macrophages Effect by Enhancing Vascular Endothelial Semaphorin 4A Exerts a Proangiogenic

The axon guidance cues semaphorins (Semas) and their receptors plexins have been shown to regulate both physiological and pathological angiogenesis. Sema4A plays an important role in the immune system by inducing T cell activation, but to date, the role of Sema4A in regulating the function of macrophages during the angiogenic and inflammatory processes remains unclear. In this study, we show th...

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Semaphorin signalling

Semaphorins are multifunctional proteins essential for embryonic development and for various physiological functions in the adult. These proteins interact with members of the plexin and neuropilin families of transmembrane receptors, leading to the activation of a diverse range of intracellular signalling events. A key characteristic of semaphorins is their ability to alter cytoskeletal dynamic...

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ژورنال

عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology

سال: 2011

ISSN: 1079-5642,1524-4636

DOI: 10.1161/atvbaha.110.215871